A database of hormones and their receptors

Receptor

Search Result - 1

HMRbase accession number	20023
Swiss-prot Accession number	Q9XSZ1 (Sequence in FASTA format)
Description	Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)].
Source organism	Papio anubis (Olive baboon)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
Subcellular location	Cell membrane; single-pass type I membrane protein (By similarity). Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain.
Tissue Specificity	N/A
Post translational modification	On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
Function	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Protein Length	638 Amino acids
Molecular weight	71407
Domain Name	N/A
References	1 PubMed abstract 10425448
Hormone	N/A
Gene ID	100126695
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 2

HMRbase accession number	20931
Swiss-prot Accession number	Q864J3 (Sequence in FASTA format)
Description	Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R).
Source organism	Papio anubis (Olive baboon)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
Subcellular location	Membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).
Protein Length	317 Amino acids
Molecular weight	34779
Domain Name	7tm_1
References	1 PubMed abstract 12687585 2 PubMed abstract 12687585
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 3

HMRbase accession number	21547
Swiss-prot Accession number	B0CM45 (Sequence in FASTA format)
Description	Nuclear receptor subfamily 2, group E, member 1 (Predicted)
Source organism	Papio anubis (Olive baboon)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
Subcellular location	Nucleus
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	385 Amino acids
Molecular weight	42589
Domain Name	Hormone_recep zf-C4
References	----
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated